What is dosage compensation

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In summary, the strategy by which C. Discrete X-recognition elements serve as entry sites to recruit the dosage compensation complex and to nucleate spreading of the complex to X regions that lack recruitment sites Figure 7. In this manner, a repressed chromatin state can be spread in cis over short or long distances, thus establishing the global regulation of X chromosomes that is maintained throughout the lifetime of hermaphrodites Csankovszki et al.

Experiments will also determine the contributions, if any, of DNA structure or specific DNA motifs within X-recognition elements for the recruitment of the dosage compensation complex to X. Ultimately, a detailed biochemical understanding of the two-fold X-chromosome repression will emerge. Akerib, C. Identification of X chromosome regions in Caenorhabditis elegans that contain sex-determination signal elements.

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Cell Biol. Chu, D. A molecular link between gene-specific and chromosome-wide transcriptional repression. Chuang, P. DPY a chromosome condensation protein homolog that regulates C. Cell 79 , — Sex-specific assembly of a dosage compensation complex on the nematode X chromosome. Science , — Csankovszki, G. Recruitment and spreading of the C. Davis, T. SDC-3 coordinates the assembly of a dosage compensation complex on the nematode X chromosome. Development , — Dawes, H.

Dosage compensation proteins targeted to X chromosomes by a determinant of hermaphrodite fate. DeLong, L. Feedback control of sex determination by dosage compensation revealed through Caenorhabditis elegans sdc-3 mutations. Fagegaltier, D. X chromosome sites autonomously recruit the dosage compensation complex in Drosophila males.

Gubbay, J. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.

Hagstrom, K. Heard, E. Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation. Cell , — Hilfiker, A. EMBO J. Hirano, T. Hodgkin, J. X chromosome dosage and gene expression in Caenorhabditis elegans : Two unusual dumpy genes. Identification of a candidate primary sex determination locus, fox-1 , on the X chromosome of Caenorhabditis elegans.

Hsu, D. The dpy gene encodes an essential component of the Caenorhabditis elegans dosage compensation machinery. Klein, R. Independent domains of the SDC-3 protein control sex determination and dosage compensation in C. Cell 72 , — Koopman, P.

Male development of chromosomally female mice transgenic for Sry. Li, W. Evidence for multiple promoter elements orchestrating male-specific regulation of the her-1 gene in Caenorhabditis elegans.

Lieb, J. MIX an essential component of the C. Cell 92 , — DPY, a link between dosage compensation and meiotic chromosome segregation in the nematode. Luz, J. XOL-1, primary determinant of sexual fate in C. Madl, J. Polyploids and sex determination in Caenorhabditis elegans. Genetics 93 , — Meller, V. Sex and the single chromosome. Mermoud, J. Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation. Meyer, B. Caenorhabditis elegans compensates for the difference in X chromosome dosage between the sexes by regulating transcript levels.

Cell 47 , — Meyer, J. Galactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiae. Miller, L. Cell 55 , — Nagy, P. A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. USA 99 , 90— Nicoll, M. X-chromosome-counting mechanisms that determine nematode sex.

Nigon, V. Polyploidie experimentale chez un nematode libre, Rhabditis elegans maupas. Nusbaum, C. The Caenorhabditis elegans gene sdc-2 controls sex determination and dosage compensation in XX animals. Oh, H. Plath, K. Xist RNA and the mechanism of X chromosome inactivation. Platt, A. The insertion of two amino acids into a transcriptional inducer converts it into a galactokinase. USA 97 , — Plenefisch, J. Genes that implement the hermaphrodite mode of dosage compensation in Caenorhabditis elegans.

Genetics , 57— Powell, J. Cell, in press. Rhind, N. Cell 80 , 71— Sinclair, A. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Skipper, M. Genetic and molecular analysis of fox-1 , a numerator element involved in Caenorhabditis elegans primary sex determination. Search inside document. Dosage Compensation Dosage Compensation The presence of different numbers of X chromosomes in males and females presents a special problem in development.

Dosage Compensation In fruit fly Drosophila melanogaster, dosage compensation is achieved by a doubling of the activity of the genes on the X chromosome of the male XY. Barr Body This highly condensed structure is about 1m in diameter, lies against the nuclear envelope of interphase cells. X-inactivation X-inactivation also called lyonization is a process by which one of the two copies of the X chromosome present in female mammals is inactivated. Documents Similar To Dosage Compensation. Rica Marquez.

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