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Benefits of Publishing. Peer Review. Publication Malpractices. Processing Charges. Biocore Conference. Research Article. Tyrosinase: Sources, Structure and Applications.
E-mail: alinawazgcu gmail. Citation: Ali Nawaz et al. DOI: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract: Tyrosinase is the natural enzymes that can be obtained from the multiple sources like bacteria, fungi, plants and mammals and can only purified to a very low degree.
Figure 1: Structure of Tyrosinase Human tyrosinases are glycoproteins which are membrane bounded and their monomers have more than one isoforms. Tyrosinase Sources: Tyrosinase can be produced and extracted through number of organisms such as bacteria, fungi, plants and mammals Table 1.
More About This Health Condition. Tyrosinase gene mutations in oculocutaneous albinism 1 OCA1 : definition of the phenotype. Hum Genet. Epub Sep Genetics of pigment cells: lessons from the tyrosinase gene family. Histol Histopathol. Oculocutaneous albinism type 1: the last years. Pigment Cell Res. The tyrosinase gene and oculocutaneous albinism type 1 OCA1 : A model for understanding the molecular biology of melanin formation. Detection of 53 novel DNA variations within the tyrosinase gene and accumulation of mutations in 17 patients with albinism.
Hum Mutat. In mammals, the melanin pigment is produced in two cell types of distinct developmental origins. The melanocytes of the skin originate form the neural crest whereas the retinal pigment epithelium RPE of the eye originates from the optic cup.
The genetic programs governing these two cell types are thus quite different but have evolved to allow the expression of pigment cell-specific genes such as the three members of the tyrosinase-related family. Tyrosinase, Tyrp1 and Dct promoters contain a motif termed E-box which is bound by the transcription factor Mitf.
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